They published new findings on taste last week in the Proceedings of the National Academy of Sciences. Previous work in Beachy's lab showed that the Hedgehog signaling pathway is often misregulated in cancers, and treatment of certain tumors involves specifically blocking the Hedgehog pathway. Stanford stem cell biologist Philip Beachy, PhD, and instructor Wan-Jin Lu, PhD, wondered about the role of a critical developmental signaling protein called Hedgehog in this loss of taste. Not only can the treatment lead to nausea, many patients also lose their sense of taste and struggle to eat enough to support their recovery. Not so for cancer patients recovering from chemotherapy. You might be thinking fondly right about now of a fantastic meal from last week (prime rib, anyone?) or eagerly anticipating a quiet lunch of leftovers. The holidays are a time of feasting for many people.
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